New hope for scoliosis

Candis health editor, Karen Evennett shares the latest health update…

Pain in the lower back in menAlthough many people haven’t heard of scoliosis – a condition causing a sideways curvature of the spine – it is surprisingly common, with three to four children per 1,000 needing specialist supervision. Now researchers looking into congenital forms of the disease say that children with rare mutations in two genes are about four times more likely to develop severe scoliosis than their peers with normal versions of the genes. The good news is that new drugs (currently in clinical trials) block a major growth pathway that these mutated genes – fibrillin-1 and fibrillin-2 – control. If the same pathway is involved in scoliosis, doctors might be able to use these drugs to prevent scoliosis in some children with these mutations.



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